Television
Sherlock Holmes
In New London, the space-scrapered London of the 22nd Century, Inspector Beth Lestrade of New Scotland Yard is chasing grotesquely deformed French rogue geneticist Martin Fenwick, when she realizes that his companion is none other than the 19th century criminal mastermind, Professor James Moriarty. (This is not the original Moriarty but in fact his clone, created from cells taken from his corpse, which Holmes had buried in a Swiss ice cave.)

Famous biologist Sir Evan Hargreaves (who looks just like Doyle) has just invented cellular rejuvenation. Beth knows that Holmes survived and actually lived to a ripe old age, and further knows that his corpse is preserved in a glass-walled, honey-filled coffin in the basement of New Scotland Yard. (This may be both a reference to the legend that Alexander the Great's body was preserved in honey, which does not rot, and also to the fact that, as stated in the original stories by Doyle, Holmes became a beekeeper once he retired.) She takes the body from the basement and delivers it to Sir Evan. The biologist then uses his cellular rejuvenation technique to return life and youth to Holmes's body, so that the detective can combat Moriarty.

As a descendant of the original Inspector Lestrade, Beth has inherited Doctor Watson's journals. When she has her law enforcement compudroid (whom she calls Watson) read them for information about Holmes, it ends up emulating the personality of the good doctor. Holmes also ends up getting his old Baker Street rooms back (they'd been preserved as a museum).

Lestrade's compudroid assumes the name, face, voice, and mannerisms of Dr. Watson to assist Holmes in both his crime-solving duties and his difficult assimilation to England in the 2100s. During the series, Holmes and Watson often work on retainer for New Scotland Yard, with Beth Lestrade as their supervising officer and Superintendent Greyson as hers, but they also work for private citizens. They are often assisted by the new Baker Street Irregulars: black soccer player Wiggins, the Eliza Doolittleish Deidre, and the paraplegic Tennyson, who communicates through electronic beeps only Holmes seems to comprehend (ironically). However, Wiggins and Deidre understand and communicate with Tennyson in The Adventure of the Dancing Men. The primary villains are Moriarty and his henchman Fenwick, but they only appear in about half of the episodes.

Interestingly, in The Adventure of the Deranged Detective, there are two references to Sir Arthur Conan Doyle. One is when Holmes is reluctant to take a case for New Scotland Yard, Lestrade jokingly says, "Or should I call on Dr. Arthur Doyle?" Holmes replies, "Oh, I will never live down that pseudonym!" Later on in the episode, Holmes introduces himself to a suspect as "Dr. Arthur Doyle" and introduces Watson as "Conan".

A sci-fi take on Arthur Conan Doyle’s classic detective story, Sherlock Holmes in the 22nd Century is like nothing you’ve seen before.

Set in New London, Inspector Beth Lestrade of New Scotland Yard is chasing grotesquely deformed French rogue geneticist Martin Fenwick, when she realizes that his companion is none other than the 19th century criminal mastermind, Professor James Moriarty. (Not the original Moriarty but in fact his clone, created from cells taken from his corpse, which Holmes had buried in a Swiss ice cave).

To combat the threat of Moriarty’s clone Scotland Yard brings back the legendary Sherlock Holmes. The defrosted detective teams with a robotic Dr Watson and a female Inspector Lestrade to stop the criminal rampage of Moriarty's new incarnation.

Holmes adapts to technology of the 22nd century strikingly well getting to grips with flying cars, monorails, and speedy journeys to resorts on the Moon.